| Cat.No.: | PE-3350 |
| Product Name: | Recombinant ALKBH5 protein |
| Product Overview: | Recombinant ALKBH5 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_060228.3) with an N-terminal FLAG-Tag. The molecular weight of ALKBH5 is 45.5 kDa. |
| Background: | N6-methylated adenine (m6A) is prevalent in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also appears in other RNA molecules, such as primary miRNA (pri-miRNAs). ALKBH5 (AlkB Homolog 5, RNA Demethylase, also known as OFOXD1, ABH5) specifically demethylates m6A RNA. ALKBH5 significantly affects mRNA export and RNA metabolism as well as the assembly of mRNA processing factors in nuclear speckles via demethylation activity. |
| Applications: | Suitable for use in enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0378 | Human ALKBH2 Knockout Cell Line 13bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0559 | ALKBH5 Chemiluminescent Assay Kit | Inquiry |
| ◆ Antibodies | ||
| EAb-0638 | ALKBH3 Polyclonal Antibody (FITC Conjugated) | Inquiry |
| EAb-0639 | ALKBH3 Polyclonal Antibody (HRP Conjugated) | Inquiry |
| EAb-0640 | ALKBH3 Polyclonal Antibody (Biotin Conjugated) | Inquiry |
| Related Gene / Proteins | |||
| ALKBH1 | ALKBH2 | ALKBH3 | ALKBH4 |
| ALKBH5 | ALKBH6 | ALKBH7 | ALKBH8 |
| ALKBH9 | |||
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