| Cat.No.: | PE-3352 |
| Product Name: | Recombinant ALKBH7 protein |
| Product Overview: | Full length ALKBH7 protein (accession number NP_115682.1) was expressed in E.coli cells with an N-terminal His tag. The molecular weights of ALKBH7 is 28.1 kDa. |
| Background: | ALKBH7 (Alkylated DNA Repair Protein AlkB Homolog 7), also called as SPATA11 (Spermatogenesis-Associated Protein 11) is a member of ALKBH protein family. It does not display DNA demethylase activity according to recent research, and may function as protein hydroxylase. It has been proved to catalyze auto-hydroxylation at Leu-110 in vitro. ALKBH7 is required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. It acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. |
| Applications: | Suitable for use in enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl pH 8.0, 300 mM NaCl, 10% glycerol, and 0.5 mM TCEP. |
| Tag: | His |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0378 | Human ALKBH2 Knockout Cell Line 13bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0559 | ALKBH5 Chemiluminescent Assay Kit | Inquiry |
| ◆ Antibodies | ||
| EAb-0638 | ALKBH3 Polyclonal Antibody (FITC Conjugated) | Inquiry |
| EAb-0639 | ALKBH3 Polyclonal Antibody (HRP Conjugated) | Inquiry |
| EAb-0640 | ALKBH3 Polyclonal Antibody (Biotin Conjugated) | Inquiry |
| Related Gene / Proteins | |||
| ALKBH1 | ALKBH2 | ALKBH3 | ALKBH4 |
| ALKBH5 | ALKBH6 | ALKBH7 | ALKBH8 |
| ALKBH9 | |||
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