| Cat.No.: | PE-3392 |
| Product Name: | Recombinant SP1 protein |
| Product Overview: | Recombinant human SP1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_612482.2) with an N-terminal FLAG tag. The molecular weight of the protein is 82.3 kDa. |
| Background: | SP1 (Specificity Protein 1), also called as Sp1 Transcription Factor or TFSP1, is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. It can bind with high affinity to GC-rich motifs and regulate the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). It may also have a role in modulating the cellular response to DNA damage and chromatin remodeling. SP1 plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, SP1 maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. It positively regulates the transcription of the core clock component ARNTL / BMAL1. Also it can play a role in the recruitment of SMARCA4 / BRG1 on the c-FOS promoter. |
| Applications: | Suitable for use in protein-protein interaction, in vitro transcription assay, binding assay. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0089 | Recombinant Human SP2 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0161 | Human SP1 Knockout Cell Line 2bp deletion | Inquiry |
| CL-0169 | Human SP140L Knockout Cell Line | Inquiry |
| CL-0170 | Human SP100 Knockout Cell Line 20bp deletion | Inquiry |
| CL-0171 | Human SP110 Knockout Cell Line 7bp deletion | Inquiry |
| Related Gene / Proteins | |||
| SP1 | SP100 | SP110 | SP140 |
| SP140L | SP2 | SP3 | SP6 |
| SPDL1 | SPF30 | SPIN1 | SPOP |
| SPT16 | SPT3 | Spt6 | SPTY2D1 |
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