| Cat.No.: | PE-3423 |
| Product Name: | Recombinant c-Myc / MAX complex |
| Product Overview: | Recombinant c-Myc / MAX Complex that includes human c-Myc amino acids 2 - 454 (accession number NP_002458.2) with an N-terminal FLAG tag and full length human MAX protein (accession number NP_660087.1) with an N-terminal 6×His tag was expressed in Sf9 cells. The molecular weights of c-Myc (2 - 454) and MAX are 51.8 kDa and 20.6 kDa, respectively. |
| Background: | c-Myc (MYC Proto-Oncogene, BHLH Transcription Factor), also known as MYCC or MRTL, is a transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Diseases associated with MYC include Burkitt Lymphoma and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and IL-2 Pathway. c-Myc can activate the transcription of growth-related genes. MAX (MYC Associated Factor X), also known as BHLHd4, is a member of transcription regulators. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD, and the MYC / MAX complex is a transcriptional activator, whereas the MAD / MAX complex is a repressor. It may repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity. c-Myc / MAX complex can specifically recognize the core sequence 5-CAC[GA]TG-3 and bind to the E box DNA consensus sequence and regulates the transcription of specific target genes. |
| Applications: | Suitable for DNA and protein-protein interaction assays. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP. |
| Tag: | FLAG & His |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0018 | Danusertib (PHA-739358) | Inquiry |
| ◆ Cell Lines | ||
| CL-0025 | Human MAGI1 Knockout Cell Line | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0058 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0059 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0074 | Recombinant Human MAGEA2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| c-Fos | c-Jun | c-MET | c-Myc |
| c-RET | MACROD2 | MAF | MAFF |
| MAGEA2 | MAGI1 | MAGOH | MAK16 |
| MALT1 | MAPK8 | MASH1 | MASP1 |
| Mat2A | MATR3 | MAX | MAZ |
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