| Cat.No.: | PE-3525 |
| Product Name: | Recombinant Histone H3/H4 tetramer |
| Product Overview: | Recombinant histone H3/K4 Tetramer consists of full length human histones H3 (accession number NP_003520.1) and full length human histone H4 (accession number NP_003539.1). Histone H3 and H4 were expressed in E. coli cells. Recombinant histone H3/H4 Tetramer was assembled by dialysis and purified by gel filtration. The molecular weight of the Histone H3/H4 Tetramer is 53 kDa. |
| Background: | Histone H3 and H4 are the core components of the nucleosome. H3 and H4 assemble H3/H4 tetramer, and H3/K4 tetramer combines with two H2A/H2B dimers to form histone octamer. The histone octamer is wrapped around by 146 bp DNA to assemble a nucleosome, which is the basic structural unit of chromatin in vivo. |
| Applications: | Suitable for use as substrates in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 10 mM Tris-HCl pH7.4, 2 M NaCl, 1 mM EDTA, 10% glycerol, and 5 mM b-mercaptoethanol. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
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