| Cat.No.: | PE-3602 |
| Product Name: | Recombinant Histone TH2B |
| Product Overview: | Recombinant Histone TH2B (accession number: NP_733759.1) was expressed in E. coli cells as full length protein without any tag. The molecular weight of TH2B is about 14.2 kDa. The recombinant histone is >95% pure by SDS-PAGE.Protein Sequence: PEVSSKGATI SKKGFKKAVV KTQKKEGKKR KRTRKESYSI YIYKVLKQVH PDTGISSKAM SIMNSFVTDI FERIASEASR LAHYSKRSTI SSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK |
| Background: | TH2B (testis-specific H2B) is originally identified as a testis-specific variant of histone H2B. TH2A is a testis-specific variant of histone H2A. They are abundant in the testis, oocytes and fertilized eggs. TH2A and TH2B are controlled by a shared promoter that is located between them. Disruption of Th2a and Th2b genes causes defects in spermatogenesis. TH2A/TH2B may enhance reprogramming by introducing processes that normally operate in zygotes and during SCNT. TH2A and TH2B induce nucleosome instability. TH2B controls the chromatin-to-nucleoprotamine transition. |
| Applications: | Suitable for use as substrate for histone modification enzymes, or to generate chromatin in vitro. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 50 mM Tris pH 8.0, 150 mM NaCl, 5% glycerol. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
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