| Cat.No.: | PE-3611 |
| Product Name: | Recombinant Histone H1 |
| Product Overview: | Full length Histone H1 (accession number NP_005309.1) was expressed in E. coli cells with no tag. The molecular weight of Histone H1 is 21 kDa. |
| Background: | Histone H1, also called as H1F0 (H1 Histone Family Member 0), is a replacement subtype, and replicationindependent histone, which is a member of the histone H1 family. It involves in basal repression of gene expression. H1 can act as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Diseases associated with H1F0 include Retinal Cancer and Deafness, Autosomal Dominant.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker- histone H1, with the DNA between the nucleosomes to form higher order chromatin structures. Histone H1 present at the interface between the nucleosome core and DNA entry/exit points. |
| Applications: | Suitable for use as substrates in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl pH 8.0, 300 mM NaCl, 10% glycerol. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
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