| Cat.No.: | PE-3708 |
| Product Name: | Recombinant KMT2B (MLL4)-SET protein |
| Product Overview: | The peptide corresponding to amino acids 2551 - 2715 of the KMT2B (MLL4)-SET protein (accession number NP_055542.1) was expressed in E. coli. The peptide contains the SET domain of MLL4 that is responsible for methyltransferase activity. Recombinant KMT2B (MLL4)-SET contains an N-terminal GST-Tag with a molecular weight of 45.2 kDa. |
| Background: | KMT2B (MLL4, Myeloid/lymphoid or mixed-lineage leukemia)-SET is a Trithorax-group protein that function collectively to promote gene expression. KMT2B (MLL4)-SET is a histone methyltransferase that methylates the Lysine 4 position of histone H3. In particular, the SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. The SET domain is responsible for its histone methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. H3K4 methylation represents a specific epigenetic tag for transcriptional activation. KMT2B (MLL4)-SET plays a central role in β-globin locus transcription regulation by being recruited by Nfe2. KMT2B (MLL4)-SET is also required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation. KMT2B (MLL4)-SET may also be involved in human cancer as its expression has been shown to be upregulated in solid tumor cell lines. |
| Applications: | Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| KMT1B | KMT1E | KMT2A | KMT2B |
| KMT2C | KMT2D | KMT2E | KMT3A |
| KMT3B | KMT3C | KMT5A | KMT6 |
| MLH1 | MLL | mll1 | MLL2 |
| MLL3 | MLL4 | MLL5 | MLLT1 More > |
| MLLT3 | SENP3 | SENP8 | SET |
| SET1 | SET2 | SET7 | SET8 |
| SET9 | SETBP1 | SETD1A | SETD1B |
| SETD2 | SETD3 | SETD5 | SETD6 |
| SETD7 | SETD8 | SETD9 | SetDB1 |
| SETDB2 | SETMAR | ||
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