| Cat.No.: | PE-3740 |
| Product Name: | MeCP2 recombinant protein |
| Description: | Active full length recombinant human N-terminal His tagged MeCP2 (Methyl CpG Binding Protein 2) protein,produced in SF9 insect cells. |
| Background: | MeCP2 (UniProt/Swiss-Prot entry P51608) is a chromosomal protein with abundant binding sites in the chromatin. It belongs tothe family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specificallyto methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interactionwith histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are thecause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mentalretardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome andsusceptibility to some types of autism. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | Purified using FPLC, >95% purity as determined by SDS-PAGE. |
| Species: | Human |
| Formulation: | 20 mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 MNaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT. |
| Alternative Names: | AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT |
| Tag: | His |
| Expression System: | Sf9 Insect Cells |
| Concentrations: | 0.5 µg/µl |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0043 | Recombinant Human MECP2 293 Cell Lysate | Inquiry |
| EL-0111 | Recombinant Human MEF2B Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0067 | MeCP2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0109 | Human MECP2 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0110 | Human MEN1 Knockout Cell Line 1bp insertion | Inquiry |
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