Cat.No.: | PE-3792 |
Product Name: | Pim 1, Active |
Background: | The proto-oncogene Pim1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus induced T-cell lymphomas in mice, Pim1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others. Expression of Pim1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Accumulating data support that the expression of Pim1 is mediated through activation of the JAK/STAT pathway. Some of the substrates of Pim1 include p21 Cip1, nuclear mitotic appartus protein, PTP-U2S and Socs-1. Recently, Pim1 has been shown to enhance the activities of p100, c-Myb and Cdc 25a and in part this might explain reported effects of Pim1 on mitogenesis. Pim1 interacts with c-Myb via the DNA binding domain and regulates its transcriptional activity. |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Appearance: | Liquid |
Molecular Weight: | 62.0 kDa |
Purity: | Purity by SDS-PAGE ≥90% |
Formulation: | 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol |
Accession#: | P11309 |
Alternative Names: | Pim, Serine/threonine-protein kinase Pim-1 |
Expression System: | Sf9 Insect Cells |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Product Types | ||
◆ Antibodies | ||
EAb-0053 | PIM1 Polyclonal Antibody | Inquiry |
EAb-0326 | PIM1 Polyclonal Antibody | Inquiry |
◆ Bioactive Small Molecules | ||
BSM-0200 | Quercetin, Dihydrate | Inquiry |
BSM-0223 | SMI-4a | Inquiry |
BSM-0271 | CUDC-907 | Inquiry |
Related Gene / Proteins | |||
PI3K | PIAS2 | PIAS4 | PIASy |
PID | PIM | PIM1 | PIM1 |
PIM2 | PITX2 | PiwiL2 | PIWIL4 |
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