Cat.No.: | EKIT-0576 |
Product Name: | SET8 Methyltransferase Inhibitor Screening Assay Kit |
Product Overview: | A convenient method for screening human SET8 inhibitors |
Description: | SET8 Methyltransferase Inhibitor Screening Assay provides a convenient method for screening human SET8 inhibitors. The transfer of the methyl group from SAM by SET8 (provided in the kit) to the acceptor peptide (H4K20) generates S-adenosylhomocysteine, which is rapidly converted to urate and hydrogen peroxide (H2O2) using an enzyme mixture provided in the kit. The H2O2 formed is quantified using 10-acetyl-3,7-dihydroxyphenoxazine (ADHP) to produce the highly fluorescent compound resorufin (excitation 530-540 nm; emission 585-595 nm). |
Background: | SET Domain-containing Protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20 (H4K20), an event proven to have an important role in chromatin structure and transcriptional activation. |
Storage: | -80°C |
Warning: | For research use only, not for diagnostic use. |
Product Types | ||
◆ Bioactive Small Molecules | ||
BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
◆ Antibodies | ||
EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
Related Gene / Proteins | |||
SENP3 | SENP8 | SET | SET1 |
SET2 | SET7 | SET8 | SET9 |
SETBP1 | SETD1A | SETD1B | SETD2 |
SETD3 | SETD5 | SETD6 | SETD7 |
SETD8 | SETD9 | SetDB1 | SETDB2 More > |
SETMAR |
USA
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