| Cat.No.: | BSM-0090 |
| Product Name: | BMS-986158 |
| CAS No.: | 1800340-40-2 |
| Figure: |
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| Synonyms: | (S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol |
| Description: | BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor. BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 495.63 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Bromodomain (BRD) and extra-terminal domain (BET) family |
| Molecular Formula: | C₃₀H₃₃N₅O₂ |
| MDL Number: | MFCD02062139 |
| Solubility: | DMSO |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0005 | BET Bromodomain Ligand | Inquiry |
| Related Gene / Proteins | |||
| BET | BRCA1 | BRCA2 | BRCC3 |
| BRD | brd1 | brd2 | brd3 |
| brd4 | BRD7 | BRD8 | brd9 |
| brdt | BRL | BRM | BRMS1 |
| BRPF1 | BRPF2 | brpf3 | BRWD1 More > |
| BRWD3 | |||
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