| Cat.No.: | BSM-0139 |
| Product Name: | GSK-J4 (Free base) |
| CAS No.: | 1373423-53-0 |
| Figure: |
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| Synonyms: | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester |
| Description: | GSK- J4 is cell-permeable ethyl ester of GSK-J1. Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. |
| Appearance: | Yellow wax. |
| Molecular Weight: | 417.5 |
| Purity: | ≥99% by TLC |
| Storage: | -20°C |
| Targets: | JMJD3/UTX |
| Molecular Formula: | C24H27N5O2 |
| MDL Number: | MFCD22683852 |
| Solubility: | DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| EAb-0075 | JMJD2b Polyclonal Antibody | Inquiry |
| EAb-0076 | JMJD2A Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | UTF1 |
| UTX | |||
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