| Cat.No.: | BSM-0193 |
| Product Name: | PFI-2 |
| CAS No.: | 1627676-59-8 |
| Figure: |
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| Synonyms: | (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide |
| Description: | PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor (IC₅₀ ~2 nM). It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd = 18 nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies. |
| Appearance: | Crystaline solid |
| Molecular Weight: | 499.52 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | SETD7 histone lysine methyltransferase |
| Molecular Formula: | C₂₃H₂₅F₄N₃O₃S |
| MDL Number: | N/A |
| Solubility: | DMSO (>30 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SENP3 | SENP8 | SET | SET1 |
| SET2 | SET7 | SET8 | SET9 |
| SETBP1 | SETD1A | SETD1B | SETD2 |
| SETD3 | SETD5 | SETD6 | SETD7 |
| SETD8 | SETD9 | SetDB1 | SETDB2 More > |
| SETMAR | |||
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