| Cat.No.: | BSM-0280 |
| Product Name: | 2-PCPA (hydrochloride) |
| CAS No.: | 1986-47-6 |
| Figure: |
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| Synonyms: | trans-2-Phenylcyclopropylamine; Tranylcypromine |
| Product Overview: | An irreversible, mechanism-based inhibitor of LSD1 |
| Description: | LSD1 shares similar catalytic sites with monoamine oxidases (MAO) A and B, the inhibition of which are used clinically to treat depression, anxiety, and Parkinson’s disease. 2-PCPA is an irreversible, mechanism-based inhibitor of LSD1 with an IC50 value of 20.7 µM and a Ki value of 242.7 µM that effectively inhibits histone demethylation in vivo. Although not as selective, 2-PCPA also irreversibly inhibits monoamine oxidase (MAO) A and MAO B with IC50 values of 2.3 and 0.95 µM and Ki values of 101.9 and 16 µM, respectively. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 169.7 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | LSD1 |
| Molecular Formula: | C9H11N • HCl |
| Chemical Name: | (1R,2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0062 | Histone Demethylase LSD1 Activity/Inhibition Assay Kit | Inquiry |
| EKIT-0126 | LSD1 Inhibitor Screening Assay Kit | Inquiry |
| EKIT-0160 | LSD1 Demethylase Activity/Inhibition Fluorometric Assay Kit | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0111 | DDP-38003 dihydrochloride | Inquiry |
| BSM-0141 | GSK-LSD1 dihydrochloride | Inquiry |
| Related Gene / Proteins | |||
| LSD1 | LSD2 | LSM2 | LSM3 |
| LSM5 | LSM6 | LSP1 | |
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