2,4-Pyridinedicarboxylic Acid

Cat.No.:	BSM-0291
Product Name:	2,4-Pyridinedicarboxylic Acid
CAS No.:	499-80-9
Figure:
Synonyms:	2,4-Dicarboxypyridine; Lutidinic Acid; NSC 403248; 2,4-PDCA
Product Overview:	An inhibitor of 2-oxoglutarate-dependent enzymes
Description:	2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.
Appearance:	A crystalline solid
Molecular Weight:	167.1
Purity:	≥98%
Storage:	-20°C
Targets:	2-oxoglutarate-dependent enzymes; Jumonji domain-containing lysine demethylases
Molecular Formula:	C7H5NO4
Chemical Name:	2,4-pyridinedicarboxylic acid
Warning:	For Research Use Only! Not For Use in Humans.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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