| Cat.No.: | BSM-0393 |
| Product Name: | RN-1 (hydrochloride) |
| CAS No.: | 1781835-13-9 |
| Figure: |
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| Synonyms: | LSD1 Inhibitor IV |
| Product Overview: | An irreversible LSD1 inhibitor |
| Description: | RN-1 is a potent, irreversible inhibitor of LSD1 (IC50 = 70 nM). It is much less effective against MAO-A and MAO-B (IC50s = 0.51 and 2.8 µM, respectively). Following intraperitoneal administration, RN-1 penetrates the blood-brain barrier and distributes in mice to a brain/plasma exposure ratio of 88.9. It blocks long-term but not short-term memory in mice. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 452.4 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | LSD1 |
| Molecular Formula: | C23H29N3O2 • 2HCl |
| Chemical Name: | RN-1, monohydrochloride |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0062 | Histone Demethylase LSD1 Activity/Inhibition Assay Kit | Inquiry |
| EKIT-0126 | LSD1 Inhibitor Screening Assay Kit | Inquiry |
| EKIT-0160 | LSD1 Demethylase Activity/Inhibition Fluorometric Assay Kit | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0111 | DDP-38003 dihydrochloride | Inquiry |
| BSM-0141 | GSK-LSD1 dihydrochloride | Inquiry |
| Related Gene / Proteins | |||
| LSD1 | LSD2 | LSM2 | LSM3 |
| LSM5 | LSM6 | LSP1 | |
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