[pSer139]Histone H2AX Polyclonal Antibody

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Cat.No.:  EAb-0223
Product Name:  [pSer139]Histone H2AX Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  Synthetic peptide corresponding to human Histone H2AX phosphorylated at Ser139.
Host:  Rabbit
Purification:  Purified from rabbit serum. Peptide affinity purified.
Appearance:  Liquid
Formulation:  In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Applications:  WB
Species Reactivity:  Human
Shipping:  Blue Ice
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Accession:  P16104
Scientific Background:  The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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