| Cat.No.: | EAb-0236 |
| Product Name: | SIRT5 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant human SIRT5. |
| Host: | Rabbit |
| Purification: | Purified from rabbit serum. Partially purified from rabbit serum with immunodepletion. |
| Appearance: | Liquid |
| Formulation: | In PBS. |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
Western Blot: (1:2,500, Colorimetric, using secondary antibody coupled to alkaline phosphatase and BCIP/NBT as substrate. / 1:3,000, ECL, using secondary antibody coupled HRP). Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, RatBovine |
| Shipping: | Dry Ice |
| Storage: | -80°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9NXA8 |
| Alternative Name: | Sirtuin-5 |
| Scientific Background: | SIRT5 is the only human class III sirtuin and as such is the closest homolog to bacterial (e.g. E. coli CobB) and archaeal sirtuins. SIRT5 is an imported mitochondrial protein with a calculated precursor molecular weight of 34kDa. In various human, rat, mouse and bovine cells and tissues, the major reactive band migrates with an apparent molecular weight of ~29kDa. This presumably reflects removal of an N-terminal transit sequence due to mitochondrial import and processing. No cross-reactivity observed with recombinant human sirtuins SIRT1, SIRT2 or SIRT3. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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