| Cat.No.: | EAb-0256 |
| Product Name: | γH2AX (phospho-Ser139) Monoclonal Antibody (Clone RM224) |
| Description: | This antibody reacts to γH2AX when phosphorylated at Ser139 and does not detect other phosphorylated histones. |
| Antibody Type: | Monoclonal |
| Clone Designation: | RM224 |
| Immunogen: | A phospho-peptide corresponding to γH2AX (phospho-Ser139) |
| Host: | Rabbit |
| Isotype: | IgG |
| Appearance: | Liquid |
| Formulation: | 100 µg protein A affinity-purified antibody from an animal origin–free culture supernatant |
| Applications: | ELISA, ICC, Multiplex, and WB |
| Species Reactivity: | All species |
| Shipping: | Wet ice |
| Storage: | -20°C |
| Storage Buffer: | 50% glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Histone H2AX, a variant of the nucleosome core histone H2A, undergoes phosphorylation on serine 139 in response to DNA damage, particularly when the damage involves formation of double-strand breaks. Phosphorylated H2AX is also termed γH2AX. Induction of γH2AX in cells exposed to genotoxic agents is considered a sensitive and specific reporter of DNA damage. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0020 | Recombinant Nucleosome, H2AR3me1 dNuc | Inquiry |
| NUC-0021 | Recombinant Nucleosome, H2AR3me2a dNuc | Inquiry |
| NUC-0075 | Recombinant Nucleosome, H2AK119ub dNuc | Inquiry |
| NUC-0076 | Recombinant Nucleosome, H2BK120ub dNuc | Inquiry |
| NUC-0082 | Recombinant Nucleosome, H2AXS139phos dNuc | Inquiry |
| Related Gene / Proteins | |||
| H2AK11 | H2AK119 | H2AK12 | H2AK13 |
| H2AK15 | H2AK16 | H2AK4 | H2AK5 |
| H2AK7 | H2AK8 | H2AK9 | H2AP26 |
| H2AQ104 | H2AR29 | H2AR3 | H2AS1 |
| H2AS129 | H2AS139 | H2AS2 | H2AT120 More > |
| H2AT121 | H2AT142 | H2AY142 | H2BK108 |
| H2BK11 | H2BK116 | H2BK12 | H2BK120 |
| H2BK126 | H2BK15 | H2BK16 | H2BK20 |
| H2BK23 | H2BK43 | H2BK46 | H2BK5 |
| H2BR79 | H2BS112 | H2BS14 | H2BS32 |
| H2BT129 | |||
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