| Cat.No.: | EAb-0270 |
| Product Name: | Histone H3.3 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | synthetic peptide from human Histone H3.3 amino acids 100-136 |
| Host: | Rabbit |
| Appearance: | Liquid |
| Formulation: | 100 µg protein A-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Applications: | IHC and WB |
| Species Reactivity: | Human Histone H3.3, Chicken Histone H3.3, Drosophila Histone H3.3, Equine Histone H3.3, Mouse Histone H3.3, Opossum Histone H3.3, Ovine Histone H3.3 |
| Shipping: | Wet ice |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | H3.3A;H3F3A;H3.3B;H3F3B |
| Scientific Background: | Histone H3.3 is a nuclear protein and a replication-independent member of the histone H3 family that has a role in nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. H3.3 constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. It has a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. Expression of H3F3A is common throughout the cell cycle independent of DNA synthesis. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
USA
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