| Cat.No.: | EAb-0290 |
| Product Name: | Histone H3K4Me2 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | Synthetic peptide from the N terminal region of human Histone H3 (di-methyl K4) conjugated to KLH. |
| Host: | mouse |
| Isotype: | IgG2aκ |
| Appearance: | Liquid |
| Formulation: | 100 µg of protein G-purified antibody |
| Applications: | FC and WB |
| Species Reactivity: | Human |
| Shipping: | Wet ice |
| Storage: | -20°C |
| Storage Buffer: | TBS, pH 7.4, with 50% glycerol, 0.1% BSA and 0.02% sodium azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P68431 |
| Alternative Name: | Histone H3 containing dimethylated lysine 4 |
| Scientific Background: | Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146 bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B, H3, and H4). Histones are subjected to numerous post-translational modifications including methylation. Histone lysine methylation is an important post-translational modification linked to diverse biological pathways including gene transcription, heterochromatin maintenance, and double-stranded DNA break repair. Most lysine methylation events are carried out by a SET domain-containing HMTase, and methylation at lysine 4 of histone 3 (H3K4) is an evolutionarily conserved modification associated with transcriptionally active chromatin. The SET1/MLL (KMT2) family of methyltransferases is the principal enzyme family responsible for H3K4 methylations. The WDR5/RbBP5/Ash21/DPY-30 subcomplex is required for the H3K4 dimethylation activity of the MLL1 core complex. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0001 | Acetyl Histone H3-K14 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0002 | Acetyl Histone H3-K14 Quantification Kit (Fluorometric) | Inquiry |
| EKIT-0003 | Acetyl Histone H3-K18 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0004 | Acetyl Histone H3-K18 Quantification Kit (Fluorometric) | Inquiry |
| EKIT-0005 | Acetyl Histone H3-K23 Quantification Kit (Colorimetric) | Inquiry |
| Related Gene / Proteins | |||
| H3K10 | H3K115 | H3K122 | H3K123 |
| H3K14 | H3K18 | H3K23 | H3K27 |
| H3K36 | H3K37 | H3K4 | H3K5 |
| H3K56 | H3K64 | H3K79 | H3K80 |
| H3K9 | H3R128 | H3R17 | H3R2 More > |
| H3R26 | H3R8 | H3R9 | H3S10 |
| H3S28 | H3S31 | H3S32 | H3T11 |
| H3T118 | H3T3 | H3T32 | H3T41 |
| H3T45 | H3T6 | H3T80 | H3Y41 |
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