Cat.No.: | EAb-0331 |
Product Name: | Phospho-Histone H2A.X (Tyr142) Polyclonal Antibody |
Antibody Type: | Polyclonal |
Immunogen: | Synthetic Peptide |
Host: | Rabbit |
Isotype: | IgG |
Purification: | Affinity purification |
Appearance: | Liquid |
Applications: | WB |
Recommended Dilutions/Conditions: |
WB: 1:1000-2000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
Species Reactivity: | Human, Mouse, Rat |
Storage: | -20°C |
Storage Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Warning: | For Research Use Only! Not For Use in Humans. |
Accession: | P16104 |
Alternative Name: | H2A histone family member X,H2A histone family member X,H2A.FX,H2A.X,H2a/x,H2AFX,H2AX,H2AX,Histone H2A.X |
Scientific Background: | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
Product Types | ||
◆ Nucleosomes | ||
NUC-0020 | Recombinant Nucleosome, H2AR3me1 dNuc | Inquiry |
NUC-0021 | Recombinant Nucleosome, H2AR3me2a dNuc | Inquiry |
NUC-0075 | Recombinant Nucleosome, H2AK119ub dNuc | Inquiry |
NUC-0076 | Recombinant Nucleosome, H2BK120ub dNuc | Inquiry |
NUC-0082 | Recombinant Nucleosome, H2AXS139phos dNuc | Inquiry |
Related Gene / Proteins | |||
H2AK11 | H2AK119 | H2AK12 | H2AK13 |
H2AK15 | H2AK16 | H2AK4 | H2AK5 |
H2AK7 | H2AK8 | H2AK9 | H2AP26 |
H2AQ104 | H2AR29 | H2AR3 | H2AS1 |
H2AS129 | H2AS139 | H2AS2 | H2AT120 More > |
H2AT121 | H2AT142 | H2AY142 | H2BK108 |
H2BK11 | H2BK116 | H2BK12 | H2BK120 |
H2BK126 | H2BK15 | H2BK16 | H2BK20 |
H2BK23 | H2BK43 | H2BK46 | H2BK5 |
H2BR79 | H2BS112 | H2BS14 | H2BS32 |
H2BT129 |
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