UBB Polyclonal Antibody


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Cat.No.:  EAb-0395
Product Name:  UBB Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  Recombinant protein of human UBB
Host:  Rabbit
Isotype:  IgG
Purification:  Affinity purification
Appearance:  Liquid
Applications:  WB, IHC, ELISA
Recommended Dilutions/Conditions:  WB: 1:500-1:2000; IHC: 1:25-1:100
Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human, Mouse, Rat
Storage:  -20°C
Storage Buffer:  PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Warning:  For Research Use Only! Not For Use in Humans.
Accession:  P0CG47
Alternative Name:  UBB,UBB,Ubiquitin
Scientific Background:  This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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