| Cat.No.: | EAb-0439 |
| Product Name: | Histone H4R3me1 Monoclonal Antibody (RM195) |
| Product Overview: | Rabbit monoclonal (RM195) to detect Histone H4 (mono methyl R3) |
| Antibody Type: | Monoclonal |
| Clone Designation: | RM195 |
| Immunogen: | A monomethyl -peptide corresponding to the Monomethyl -Histone H4 [Methyl Arg3](RM195) |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | HIST4H4, Monomethyl Arg3 |
| Specificity: | This antibody reacts to Histone H4 monomethylated at Arginine 3 (R3me1). No cross reactivity with unmodified Arginine 3, asymmetric or symmetric dimethylated Arginine 3, and citrullinated Arginine 3 in Histone H4. |
| Purification: | Protein A purified |
| Appearance: | Liquid |
| Formulation: | 50% Glycerol/PBS with 1% BSA |
| Applications: | WB, ELISA, ICC/IF, MI |
| Recommended Dilutions/Conditions: |
Western Blot; ELISA 0.2 ug/mL - 1 ug/mL; Immunocytochemistry/Immunofluorescence 1 ug/mL- 2 ug/mL; Multiplex Immunoassay Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Storage Buffer: | 0.09% Sodium Azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | H4; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4/p; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; histone 4, H4; Histone Cluster 1 H4; Histone Cluster 1 H4i; Histone Cluster 4 H4; histone cluster 4, H4; Histone H4; MGC24116 |
| Scientific Background: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0011 | Histone H4 peptide (1-21), Dimethyl R3, Biotin-labeled | Inquiry |
| ◆ Research Kits | ||
| EKIT-0013 | Acetyl Histone H4K12 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0014 | Acetyl Histone H4K12 Quantification Kit (Fluorometric) | Inquiry |
| EKIT-0015 | Acetyl Histone H4K16 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0016 | Acetyl Histone H4K16 Quantification Kit (Fluorometric) | Inquiry |
| Related Gene / Proteins | |||
| H4H18 | H4K12 | H4K16 | H4K20 |
| H4K31 | H4K44 | H4K5 | H4K59 |
| H4K79 | H4K8 | H4K91 | H4R3 |
| H4S1 | H4S47 | H4T30 | H4T80 |
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