| Cat.No.: | EAb-0466 |
| Product Name: | DNMT3B Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant protein encompassing a sequence within the C-terminus region of mouse DNMT3B. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | DNMT3B |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | PBS (pH 7), 20% Glycerol |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
Western Blot 1:500-1:3000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, Rat, Bovine |
| Storage: | -20°C |
| Storage Buffer: | 0.01% Thimerosal |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9UBC3 |
| Alternative Name: | DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; DNMT3B; EC 2.1.1.37; ICF; ICF1; M.HsaIIIB |
| Scientific Background: | Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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