| Cat.No.: | EAb-0500 |
| Product Name: | Histone H3K36ac Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthetic acetylated peptide surrounding Lysine 36 of human Histone H3.2 [Swiss Prot Q71DI3]. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | HIST2H3C, ac Lys36 |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | PBS and 30% Glycerol |
| Applications: | WB, DB |
| Recommended Dilutions/Conditions: |
Western Blot 1:1000; Dot Blot 1:1000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, C. Elegans, Rat, Chicken, Drosophilia, Plant, Xenopus |
| Storage: | -20°C |
| Storage Buffer: | 0.05% Sodium Azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | H3 histone, family 3A; H3.3AH3F3H3F3B; H3.3B; H3F3A; Histone H3; histone H3.3; MGC87782; MGC87783 |
| Scientific Background: | Histone H3 acetylation at lysine 36 results from the activity of GCN5, which regulates transcription. H3K36ac is usually found in the promoters of RNA polymerase II-transcribed genes. When acetylation of this lysine is replaced by methylation, the activation of transcription is eliminated. This switch-like activity seems to determine the chromatin function found in transcription units. Set2 associates with RNA polymerase II and histone H3 at lysine 36, and seems to be responsible for proper acetylation of coding regions. The co-activity of Set2 and Rpd3S is important for ensuring that transcription of intragenic sequences does not occur, and is related to the acetylation and methylation of histone H3 at lysine 36. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0001 | Acetyl Histone H3-K14 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0002 | Acetyl Histone H3-K14 Quantification Kit (Fluorometric) | Inquiry |
| EKIT-0003 | Acetyl Histone H3-K18 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0004 | Acetyl Histone H3-K18 Quantification Kit (Fluorometric) | Inquiry |
| EKIT-0005 | Acetyl Histone H3-K23 Quantification Kit (Colorimetric) | Inquiry |
| Related Gene / Proteins | |||
| H3K10 | H3K115 | H3K122 | H3K123 |
| H3K14 | H3K18 | H3K23 | H3K27 |
| H3K36 | H3K37 | H3K4 | H3K5 |
| H3K56 | H3K64 | H3K79 | H3K80 |
| H3K9 | H3R128 | H3R17 | H3R2 More > |
| H3R26 | H3R8 | H3R9 | H3S10 |
| H3S28 | H3S31 | H3S32 | H3T11 |
| H3T118 | H3T3 | H3T32 | H3T41 |
| H3T45 | H3T6 | H3T80 | H3Y41 |
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