| Cat.No.: | EAb-0584 |
| Product Name: | Histone H2A.Zac Polyclonal Antibody |
| Product Overview: | Anti-Histone H2 A.Zac (RABBBIT) Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Produced in rabbits by repeated immunization with a synthetic peptide containing the region of human histone H2A.Z acetylated at lysines 5, 7 and 11. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Purified by affinity purification. |
| Appearance: | Liquid |
| Formulation: | 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2 |
| Applications: | Chromatin Immunoprecipitation, Dot Blotting, ELISA, Immunofluorescence and Western Blots |
| Recommended Dilutions/Conditions: |
ELISA: 1:500 ChIP: 1 μg/ChIP; IF Microscopy: 1:500; Western Blot: 1:1,000; Dot Blot: 20,000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Cross Reactivity: | Human, Mouse, wide range expected |
| Shipping: | Dry Ice |
| Storage: | -20°C |
| Storage Buffer: | 0.05% (w/v) Sodium Azide and 0.05% ProClin 300 |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | UniProtKB - P0C0S5; GeneID - 3015; NCBI - NP_002097 |
| Alternative Name: | Histone H2A.Z, H2A/z |
| Scientific Background: | Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called “histone code”. Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Acetylation of the histone H2A variant H2A.Z is associated with the promoters of active genes. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0020 | Recombinant Nucleosome, H2AR3me1 dNuc | Inquiry |
| NUC-0021 | Recombinant Nucleosome, H2AR3me2a dNuc | Inquiry |
| NUC-0075 | Recombinant Nucleosome, H2AK119ub dNuc | Inquiry |
| NUC-0076 | Recombinant Nucleosome, H2BK120ub dNuc | Inquiry |
| NUC-0082 | Recombinant Nucleosome, H2AXS139phos dNuc | Inquiry |
| Related Gene / Proteins | |||
| H2AK11 | H2AK119 | H2AK12 | H2AK13 |
| H2AK15 | H2AK16 | H2AK4 | H2AK5 |
| H2AK7 | H2AK8 | H2AK9 | H2AP26 |
| H2AQ104 | H2AR29 | H2AR3 | H2AS1 |
| H2AS129 | H2AS139 | H2AS2 | H2AT120 More > |
| H2AT121 | H2AT142 | H2AY142 | H2BK108 |
| H2BK11 | H2BK116 | H2BK12 | H2BK120 |
| H2BK126 | H2BK15 | H2BK16 | H2BK20 |
| H2BK23 | H2BK43 | H2BK46 | H2BK5 |
| H2BR79 | H2BS112 | H2BS14 | H2BS32 |
| H2BT129 | |||
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