| Cat.No.: | EAb-0614 |
| Product Name: | Histone H4 pan Polyclonal Antibody |
| Product Overview: | Anti-Histone H4 pan (RABBIT) Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Produced in rabbits by repeated immunizations with a synthetic peptide containing a sequence from the internal region of histone H4. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Purified by affinity purification. |
| Appearance: | Liquid |
| Formulation: | 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2 |
| Applications: | Chromatin Immunoprecipitation, Dot Blots and ELISA |
| Recommended Dilutions/Conditions: |
ELISA: 1:500 ChIP: 2-5 μg per IP; Dot Blot: 1:10,000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Cross Reactivity: | Human |
| Shipping: | Dry Ice |
| Storage: | -20°C |
| Storage Buffer: | 0.05% (w/v) Sodium Azide and 0.05% ProClin 300 |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | UniProtKB - P62805; GeneID - 121504; NCBI - NP_001029249 |
| Alternative Name: | Histone H4, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4J, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 |
| Scientific Background: | Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histones play a internal role in the regulation of transcription, DNA repair, DNA replication and chromosomal stability. These different functions are established via a complex set of post-translational modifications which either directly or indirectly alter chromatin structure and DNA accessibility to facilitate transcriptional activation or repression or other nuclear processes. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
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