Cat.No.: | EAb-0619 |
Product Name: | Histone H3 K9ac/pS10 Polyclonal Antibody |
Product Overview: | Anti-Histone H3 [ac Lys9/phospho Ser10] (RABBIT) Antibody |
Antibody Type: | Polyclonal |
Immunogen: | Prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide with a acetylation surrounding Lysine 9 and a phosphorylation surrounding serine 10 of human Histone H3. |
Host: | Rabbit |
Isotype: | IgG |
Purification: | Affinity purified from monospecific antiserum by immunoaffinity chromatography. |
Appearance: | Liquid |
Formulation: | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
Applications: | Western Blot, Dot Blot, and Immunocytochemistry/Immunofluorescence |
Recommended Dilutions/Conditions: |
IF Microscopy : 1:10; Western Blot: 1.0 µg/mL Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
Cross Reactivity: | Human |
Shipping: | Dry Ice |
Storage: | -20°C |
Storage Buffer: | 0.01% (w/v) Sodium Azide |
Warning: | For Research Use Only! Not For Use in Humans. |
Accession: | UniprotKB - Q71DI3; NCBI - NP_001005464; GeneID - 126961 |
Alternative Name: | rabbit anti-Histone H3 Ac Lys9 pS10 antibody, Histone H3 antibodies, H3K9ac/pS10 |
Scientific Background: | Histones of the nucleosome build chromatin and undergo various post-translational modifications proven to regulate chromatin condensation and DNA accessibility. Phosphorylations on Serine 10 has been shown to facilitate chromatin condensation by its interaction with Aurora-B kinase during mitosis and is alternatively active in cell division. Serine modification is associated with IKK-alpha and Snf1 enzymes in transcriptional activation, and is modified by MSK1 and 2 which are enzymes that react to growth factors and cellular stress in immediate-early gene activation. Lysine 9 acetylations are connected with histone deposition and transcriptional activation. |
Product Types | ||
◆ Research Kits | ||
EKIT-0001 | Acetyl Histone H3-K14 Quantification Kit (Colorimetric) | Inquiry |
EKIT-0002 | Acetyl Histone H3-K14 Quantification Kit (Fluorometric) | Inquiry |
EKIT-0003 | Acetyl Histone H3-K18 Quantification Kit (Colorimetric) | Inquiry |
EKIT-0004 | Acetyl Histone H3-K18 Quantification Kit (Fluorometric) | Inquiry |
EKIT-0005 | Acetyl Histone H3-K23 Quantification Kit (Colorimetric) | Inquiry |
Related Gene / Proteins | |||
H3K10 | H3K115 | H3K122 | H3K123 |
H3K14 | H3K18 | H3K23 | H3K27 |
H3K36 | H3K37 | H3K4 | H3K5 |
H3K56 | H3K64 | H3K79 | H3K80 |
H3K9 | H3R128 | H3R17 | H3R2 More > |
H3R26 | H3R8 | H3R9 | H3S10 |
H3S28 | H3S31 | H3S32 | H3T11 |
H3T118 | H3T3 | H3T32 | H3T41 |
H3T45 | H3T6 | H3T80 | H3Y41 |
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