Cat.No.: | EAb-1102 |
Product Name: | Phospho Histone H2AX (S139) Monoclonal Antibody [RMC097A] |
Antibody Type: | Monoclonal |
Conjugate: | Unconjugated |
Host: | Rabbit |
Isotype: | IgG |
Purification: | Affinity Purified |
Appearance: | Liquid |
Formulation: | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Applications: | ELISA, WB |
Recommended Dilutions/Conditions: |
ELISA, WB; Recommended dilution: WB: 1:3000-1:10000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
Species Reactivity: | Human |
Storage: | -20°C |
Warning: | For Research Use Only! Not For Use in Humans. |
Alternative Name: | Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX |
Scientific Background: | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
Product Types | ||
◆ Nucleosomes | ||
NUC-0020 | Recombinant Nucleosome, H2AR3me1 dNuc | Inquiry |
NUC-0021 | Recombinant Nucleosome, H2AR3me2a dNuc | Inquiry |
NUC-0075 | Recombinant Nucleosome, H2AK119ub dNuc | Inquiry |
NUC-0076 | Recombinant Nucleosome, H2BK120ub dNuc | Inquiry |
NUC-0082 | Recombinant Nucleosome, H2AXS139phos dNuc | Inquiry |
Related Gene / Proteins | |||
H2AK11 | H2AK119 | H2AK12 | H2AK13 |
H2AK15 | H2AK16 | H2AK4 | H2AK5 |
H2AK7 | H2AK8 | H2AK9 | H2AP26 |
H2AQ104 | H2AR29 | H2AR3 | H2AS1 |
H2AS129 | H2AS139 | H2AS2 | H2AT120 More > |
H2AT121 | H2AT142 | H2AY142 | H2BK108 |
H2BK11 | H2BK116 | H2BK12 | H2BK120 |
H2BK126 | H2BK15 | H2BK16 | H2BK20 |
H2BK23 | H2BK43 | H2BK46 | H2BK5 |
H2BR79 | H2BS112 | H2BS14 | H2BS32 |
H2BT129 |
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