Phospho Histone H3 (Thr11) Polyclonal Antibody


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Cat.No.:  EAb-1134
Product Name:  Phospho Histone H3 (Thr11) Polyclonal Antibody
Antibody Type:  Polyclonal
Conjugate:  Unconjugated
Host:  Rabbit
Isotype:  IgG
Purification:  Affinity Purified
Appearance:  Liquid
Formulation:  PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Applications:  ELISA, WB
Recommended Dilutions/Conditions:  WB, ELISA; Recommended dilution: WB:1/500-1/1000, ELISA:1/20000
Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human, Mouse, Rat
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Scientific Background:  Histone H3 along with H2A, H2B and H4 is involved in the structure of chromatin in eukaryotic cells. Histone H3 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications, including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation, occur on the N-terminal tail domains of histone H3, which results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. In most species, histone H3 is primarily phosphorylated at serine 10, serine 28, threonine 3 and theonine11.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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