Cat.No.: | EAb-1218 |
Product Name: | PSMD10 Polyclonal Antibody, FITC Conjugated |
Antibody Type: | Polyclonal |
Conjugate: | FITC |
Host: | Rabbit |
Isotype: | IgG |
Purification: | Protein G Purified |
Appearance: | Liquid |
Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
Applications: | ELISA |
Species Reactivity: | Human |
Storage: | -20°C |
Warning: | For Research Use Only! Not For Use in Humans. |
Alternative Name: | 26S proteasome regulatory subunit p28, Gankyrin, p28(GANK), PSMD10 |
Scientific Background: | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. |
Product Types | ||
◆ Cell Lines | ||
CL-0120 | Human PSMB9 Knockout Cell Line 4bp deletion | Inquiry |
CL-0122 | Human PSMB8 Knockout Cell Line 2bp deletion | Inquiry |
CL-0166 | Human PSG1 Knockout Cell Line | Inquiry |
◆ Proteins & Enzymes | ||
PE-0904 | Recombinant Zebrafish PSME4B | Inquiry |
◆ Antibodies | ||
EAb-1167 | PSMG3 Polyclonal Antibody, HRP Conjugated | Inquiry |
Related Gene / Proteins | |||
PSD3 | PSG1 | PSMA7 | PSMB1 |
PSMB2 | PSMB4 | PSMB7 | PSMB8 |
PSMB9 | PSMC3 | PSMC6 | PSMD10 |
PSMD11 | PSMD2 | PSMD7 | PSME2 |
PSME3 | PSME4B | PSMF1 | PSMG3 |
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