| Cat.No.: | EAb-1219 |
| Product Name: | PSMD10 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Conjugate: | Unconjugated |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA, IF, IHC |
| Recommended Dilutions/Conditions: |
ELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:200-1:500 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | 26S proteasome regulatory subunit p28, Gankyrin, p28(GANK), PSMD10 |
| Scientific Background: | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0120 | Human PSMB9 Knockout Cell Line 4bp deletion | Inquiry |
| CL-0122 | Human PSMB8 Knockout Cell Line 2bp deletion | Inquiry |
| CL-0166 | Human PSG1 Knockout Cell Line | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0904 | Recombinant Zebrafish PSME4B | Inquiry |
| ◆ Antibodies | ||
| EAb-1167 | PSMG3 Polyclonal Antibody, HRP Conjugated | Inquiry |
| Related Gene / Proteins | |||
| PSD3 | PSG1 | PSMA7 | PSMB1 |
| PSMB2 | PSMB4 | PSMB7 | PSMB8 |
| PSMB9 | PSMC3 | PSMC6 | PSMD10 |
| PSMD11 | PSMD2 | PSMD7 | PSME2 |
| PSME3 | PSME4B | PSMF1 | PSMG3 |
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