| Cat.No.: | EAb-1310 |
| Product Name: | KLHL22 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Conjugate: | Unconjugated |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA, WB |
| Recommended Dilutions/Conditions: |
ELISA, WB; Recommended dilution: WB:1:500-2000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | Kelch-like protein 22, KLHL22 |
| Scientific Background: | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0185 | KLF13 Polyclonal Antibody | Inquiry |
| EAb-0312 | KLLN Polyclonal Antibody | Inquiry |
| EAb-1163 | KLHL41 Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1164 | KLHL41 Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1165 | KLHL41 Polyclonal Antibody, Biotin Conjugated | Inquiry |
| Related Gene / Proteins | |||
| KLF13 | KLF17 | KLF4 | KLF5 |
| KLF6 | KLHDC8A | KLHL12 | KLHL17 |
| KLHL2 | KLHL22 | KLHL23 | KLHL34 |
| KLHL38 | KLHL41 | KLHL42 | KLLN |
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