| Cat.No.: | EAb-1314 |
| Product Name: | KLHL12 Polyclonal Antibody, HRP Conjugated |
| Antibody Type: | Polyclonal |
| Conjugate: | HRP |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | Kelch-like protein 12, KLHL12, C3IP1, CUL3-interacting protein 1, DKIR homolog, hDKIR |
| Scientific Background: | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0185 | KLF13 Polyclonal Antibody | Inquiry |
| EAb-0312 | KLLN Polyclonal Antibody | Inquiry |
| EAb-1163 | KLHL41 Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1164 | KLHL41 Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1165 | KLHL41 Polyclonal Antibody, Biotin Conjugated | Inquiry |
| Related Gene / Proteins | |||
| KLF13 | KLF17 | KLF4 | KLF5 |
| KLF6 | KLHDC8A | KLHL12 | KLHL17 |
| KLHL2 | KLHL22 | KLHL23 | KLHL34 |
| KLHL38 | KLHL41 | KLHL42 | KLLN |
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