| Cat.No.: | EAb-1928 |
| Product Name: | MALT1 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This MALT1 antibody was raised against a recombinant protein corresponding to amino acids 701-808 of mouse MALT1. |
| Host: | Mouse |
| Isotype: | IgG |
| Molecular Weight: | 92 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 0.5 - 2 µg/ml dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | MALT1 enhances Bcl10-induced activation of NFκB and is also involved in nuclear export of Bcl10. MALT1 binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. MALT1-dependent Bcl10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. MALT1 was independently identified as a protein of 824 amino acids, and human MALT2 isoform b is an amino acid protein of 813 amino acids. MALT1 is thought to play a role in NFκB signaling by enhancing NFκB (NFκB p50 & NFκB p65) activation through interaction with Bcl10. Interaction between MALT1 and Bcl10 mediates IKK (IKKα, IKKβ, IKKi/IKKε and IKKγ) activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0025 | Human MAGI1 Knockout Cell Line | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0058 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0059 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0074 | Recombinant Human MAGEA2 293 Cell Lysate | Inquiry |
| EL-0096 | Recombinant Human MACROD2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| MACROD2 | MAF | MAFF | MAGEA2 |
| MAGI1 | MAGOH | MAK16 | MALT1 |
| MAPK8 | MASH1 | MASP1 | Mat2A |
| MATR3 | MAX | MAZ | |
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