| Cat.No.: | EAb-2034 |
| Product Name: | Histone H1.5S17ph Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This Histone H1.5 phospho Ser17 antibody was raised against a peptide containing phospho Ser17 of human histone H1.5. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 36 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Wide Range Predicted |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points; it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; they play a major role in regulating gene expression. Histone H1.5 is an H1 isotype expressed in somatic cells and is heavily phosphorylated during mitosis. Phosphorylation of H1.5 at serine 17 appears in prometaphase and disappears in telophase. The hyperphosphorylated form of H1.5 is mainly chromatin-bound in metaphase when chromatin is maximally condensed. Phosphorylation of H1.5 at serine 17 can be catalyzed by GSK-3. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0265 | Histone H1.4 (Citrullinated R53) Polyclonal Antibody | Inquiry |
| EAb-0761 | Histone H1 K25me3 Polyclonal Antibody | Inquiry |
| EAb-0766 | Histone H1K25me2 (H1K25 Dimethyl) Polyclonal Antibody | Inquiry |
| EAb-0767 | Histone H1K25me1 (H1K25 Monomethyl) Polyclonal Antibody | Inquiry |
| EAb-1076 | Histone H1K25ac (Acetyl H1K25) Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| H1K109 | H1K158 | H1K25 | H1K26 |
| H1K52 | H1K96 | H1R53 | H1S1 |
| H1S17 | H1S26 | H1T146 | H1T17 |
| H1T18 | H1T3 | ||
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