Cat.No.: | EAb-2072 |
Product Name: | ATF4 Polyclonal Antibody |
Antibody Type: | Polyclonal |
Immunogen: | This antibody was raised against a recombinant protein to human ATF4. |
Host: | Rabbit |
Isotype: | IgG |
Molecular Weight: | 42 kDa |
Purification: | Affinity Purified |
Appearance: | Liquid |
Formulation: | Purified IgG in PBS with 50% glycerol and 0.02% sodium azide. |
Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
Species Reactivity: | Human |
Storage: | -20°C |
Warning: | For Research Use Only! Not For Use in Humans. |
Scientific Background: | ATF4 (Activating Transcription Factor 4) is a transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. |
Product Types | ||
◆ Cell Lines | ||
CL-0020 | Human ATAD2 Knockout Cell Line 2bp deletion | Inquiry |
CL-0021 | Human ATAD2B Knockout Cell Line 130bp insertion | Inquiry |
CL-0022 | Human ATAD2B Knockout Cell Line 130bp insertion | Inquiry |
◆ Research Kits | ||
EKIT-0021 | ATF2 (pT69/pT71) Transcription Factor Assay Kit | Inquiry |
◆ Extracts & Lysates | ||
EL-0031 | Recombinant Human ATAD2 293 Cell Lysate | Inquiry |
Related Gene / Proteins | |||
ATAD2 | ATAT1 | ATF-6 | ATF1 |
ATF2 | ATF4 | ATM | ATR |
ATRX | ATXN3 | ATXN3L | ATXN7 |
ATXN7L3 |
USA
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