Histone H2BS14ph Monoclonal Antibody

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Cat.No.:  EAb-2158
Product Name:  Histone H2BS14ph Monoclonal Antibody
Antibody Type:  Monoclonal
Immunogen:  This Histone H2B phospho Ser14 antibody was raised against a peptide containing phospho Ser14 of human histone H2B.
Host:  Mouse
Isotype:  IgG1
Molecular Weight:  15 kDa
Purification:  Protein G Chromatography
Appearance:  Liquid
Formulation:  PBS pH 7.5 containing 30% glycerol and 0.035% sodium azide.
Applications:  ICC/IF; WB
Species Reactivity:  Human, Wide Range Predicted
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Scientific Background:  Histone H2B is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points. Histone H1 is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins. H2B is phosphorylated at serine 14 in response to DNA damage (dependant upon PI3 kinase kinase activity) and during apoptosis.by the Mst1 kinase.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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