Histone H3K14me1 Polyclonal Antibody


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Cat.No.:  EAb-2229
Product Name:  Histone H3K14me1 Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  This antibody was raised against a peptide including monomethyl-lysine 14 of human histone H3.
Host:  Rabbit
Isotype:  Serum
Molecular Weight:  17 kDa
Purification:  Affinity Purified
Appearance:  Liquid
Formulation:  Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.
Applications:  WB: 1:500 - 1:2,500 dilution; IF: 1:500 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human, Wide Range Predicted
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Accession:  Swiss Prot Q16695; Gene ID 8290
Alternative Name:  HIST3H3; H3.4; H3/g; H3FT; H3t; histone H3.1t
Scientific Background:  Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression. Histone methylation can be associated with transcriptional activation or repression, depending on the methylated residue.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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