| Cat.No.: | EAb-2277 |
| Product Name: | Histone H2AT120ph Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This Histone H2A phospho Thr120 antibody was raised against a peptide containing phospho-threonine 120 of histone H2A. |
| Host: | Rabbit |
| Isotype: | Serum |
| Molecular Weight: | 16 kDa |
| Purification: | None |
| Appearance: | Liquid |
| Formulation: | Rabbit serum containing 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:2,500 - 1:10,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Wide Range Predicted |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Histone H2A is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points; it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; they play a major role in regulating gene expression.Phosphorylation of histones occurs at multiple sites during mitosis. H2A Thr120 phosphorylation is observed on chromatin during both mitosis and meiosis. Thr120 phosphorylation is inversely correlated with ubiquitylation of H2A Lys119 in meiotic mouse spermatocytes. In Drosophila, loss of H2A Thr120 phosphorylation is associated with a failure to disassemble the synaptonemal complex, impaired loading of condensin and female infertility. It is possible that H2A Thr120 phosphorylation is involved in the regulation of chromatin structure. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0020 | Recombinant Nucleosome, H2AR3me1 dNuc | Inquiry |
| NUC-0021 | Recombinant Nucleosome, H2AR3me2a dNuc | Inquiry |
| NUC-0075 | Recombinant Nucleosome, H2AK119ub dNuc | Inquiry |
| NUC-0076 | Recombinant Nucleosome, H2BK120ub dNuc | Inquiry |
| NUC-0082 | Recombinant Nucleosome, H2AXS139phos dNuc | Inquiry |
| Related Gene / Proteins | |||
| H2AK11 | H2AK119 | H2AK12 | H2AK13 |
| H2AK15 | H2AK16 | H2AK4 | H2AK5 |
| H2AK7 | H2AK8 | H2AK9 | H2AP26 |
| H2AQ104 | H2AR29 | H2AR3 | H2AS1 |
| H2AS129 | H2AS139 | H2AS2 | H2AT120 More > |
| H2AT121 | H2AT142 | H2AY142 | H2BK108 |
| H2BK11 | H2BK116 | H2BK12 | H2BK120 |
| H2BK126 | H2BK15 | H2BK16 | H2BK20 |
| H2BK23 | H2BK43 | H2BK46 | H2BK5 |
| H2BR79 | H2BS112 | H2BS14 | H2BS32 |
| H2BT129 | |||
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