Cat.No.: | EAb-2455 |
Product Name: | ARID5B Polyclonal Antibody (N-terminal) |
Product Overview: | Rabbit polyclonal to detect ARID5B - N-terminal |
Antibody Type: | Polyclonal |
Immunogen: | Synthetic peptide within Human ARID5B aa 77-126 (N terminal). Isoform 3. |
Immunogen Sequence: | FLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHA |
Host: | Rabbit |
Isotype: | IgG |
Purification: | Immunogen affinity purified |
Appearance: | Liquid |
Formulation: | 0.09% Sodium azide, 2% Sucrose, PBS |
Applications: | WB |
Species Reactivity: | Human |
Storage: | -20°C. |
Warning: | For Research Use Only! Not For Use in Humans. |
Accession: | Q14865-3 |
Alternative Name: | ARI5B_HUMAN antibody/ARID domain-containing protein 5B antibody/Arid5b antibody |
Scientific Background: | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. |
Product Types | ||
◆ Cell Lines | ||
CL-0001 | Human ARHGEF1 Knockout Cell Line 8bp deletion | Inquiry |
CL-0002 | Human ARHGEF15 Knockout Cell Line | Inquiry |
CL-0003 | Human ARHGEF11 Knockout Cell Line | Inquiry |
CL-0004 | Human ARHGEF10L Knockout Cell Line | Inquiry |
CL-0005 | Human ARHGEF12 Knockout Cell Line | Inquiry |
Related Gene / Proteins | |||
ARD1A | ARF1 | ARHGEF1 | ARHGEF10 |
ARHGEF10L | ARHGEF11 | ARHGEF12 | ARHGEF15 |
ARHGEF16 | ARHGEF17 | ARHGEF18 | ARHGEF19 |
ARID1A | ARID1B | ARID2 | ARID3A |
ARID4A | ARID5A | ARID5B | ARIH2 More > |
AROS | ARTD10 |
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