EZH1 Polyclonal Antibody


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Cat.No.:  EAb-2558
Product Name:  EZH1 Polyclonal Antibody
Product Overview:  Rabbit polyclonal to detect EZH1
Antibody Type:  Polyclonal
Immunogen:  Synthetic peptide (Human) from an internal region of EZH1.
Host:  Rabbit
Isotype:  IgG
Purification:  Immunogen affinity purified
Appearance:  Liquid
Formulation:  pH: 7.40; 0.02% Sodium azide, PBS, 50% Glycerol, 0.87% Sodium chloride (PBS without Mg2+ and Ca2+)
Applications:  WB, IHC-P, ELISA
Species Reactivity:  Mouse, Human
Storage:  -20°C.
Warning:  For Research Use Only! Not For Use in Humans.
Accession:  Q92800
Alternative Name:  Enhancer of zeste homolog 1 (Drosophila) antibody/Enhancer of zeste homolog 1 antibody/ENX-2 antibody
Scientific Background:  Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
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◆ Extracts & Lysates
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Related Gene / Proteins
ezh1 EZH2

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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