Cat.No.: | EAb-2742 |
Product Name: | EZH2 Monoclonal Antibody (SP129) - Azide and BSA free |
Product Overview: | Rabbit monoclonal (SP129) to detect KMT6/EZH2 - Azide and BSA free |
Antibody Type: | Monoclonal |
Clone Designation: | SP129 |
Immunogen: | Synthetic peptide within Human KMT6/ EZH2 aa 300-400. |
Host: | Rabbit |
Isotype: | IgG |
Purification: | Protein A/G purified |
Appearance: | Liquid |
Formulation: | PBS |
Applications: | WB, IHC-P, Flow Cyt |
Species Reactivity: | Human |
Storage: | -20°C. |
Warning: | For Research Use Only! Not For Use in Humans. |
Accession: | Q15910 |
Alternative Name: | EZH2; ENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2; histone-lysine N-methyltransferase EZH2 |
Scientific Background: | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. |
Product Types | ||
◆ Bioactive Small Molecules | ||
BSM-0006 | GSK343 | Inquiry |
BSM-0059 | 3-Deazaneplanocin A | Inquiry |
BSM-0060 | 3-Deazaneplanocin A hydrochloride | Inquiry |
◆ Extracts & Lysates | ||
EL-0024 | Recombinant Human EZH1 293 Cell Lysate | Inquiry |
EL-0025 | Recombinant Human EZH2 293 Cell Lysate | Inquiry |
Related Gene / Proteins | |||
ezh1 | EZH2 |
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