| Cat.No.: | EAb-2951 |
| Product Name: | KMT5A/SETD8/Pr-SET7 Polyclonal Antibody |
| Product Overview: | Rabbit polyclonal to detect KMT5A/SETD8/Pr-SET7 |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant full length protein (His-DDDDK-tag) corresponding to Human KMT5A/ SETD8/ Pr-SET7. (DDDDK-tagged N-terminus and His-tagged C terminus). |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Whole antiserum |
| Appearance: | Liquid |
| Formulation: | 0.05% Sodium azide |
| Applications: | WB |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9NQR1 |
| Alternative Name: | H4 K20 HMTase antibody/H4 K20 specific histone methyltransferase antibody/H4-K20-HMTase SETD8 antibody |
| Scientific Background: | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
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