| Cat.No.: | EAb-2961 |
| Product Name: | EHMT1/GLP Monoclonal Antibody |
| Product Overview: | Mouse monoclonal to detect EHMT1/GLP |
| Antibody Type: | Monoclonal |
| Immunogen: | Recombinant fragment corresponding to Human EHMT1/GLP aa 933-1254. (SET domain). |
| Immunogen Sequence: | HAVNIHGD SPLHIAAREN |
| Host: | Mouse |
| Isotype: | IgG1 |
| Purification: | Affinity purified |
| Appearance: | Liquid |
| Formulation: | 0.09% Sodium azide, 99% PBS |
| Applications: | IP, MS |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9H9B1 |
| Alternative Name: | EHMT1; EUHMTASE1; Eu-HMTase1; FP13812; GLP; GLP1; KMT1D; bA188C12.1; histone-lysine N-methyltransferase EHMT1 |
| Scientific Background: | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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