SET7 Polyclonal Antibody - Biotin

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Cat.No.:  EAb-2980
Product Name:  SET7 Polyclonal Antibody - Biotin
Product Overview:  Rabbit polyclonal to detect SET7 (Biotin)
Antibody Type:  Polyclonal
Immunogen:  Recombinant full length protein corresponding to Human SET7.
Host:  Rabbit
Isotype:  IgG
Purification:  Protein G purified
Appearance:  Liquid
Formulation:  0.01% Thimerosal (merthiolate)
Applications:  WB, ELISA, RIA
Species Reactivity:  Human
Storage:  -20°C.
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  FLJ21193 antibody/H3 K4 HMTase antibody/H3-K4-HMTase SETD7 antibody
Scientific Background:  Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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