Histone H3.3 pS31 Polyclonal Antibody


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Cat.No.:  EAb-3124
Product Name:  Histone H3.3 pS31 Polyclonal Antibody
Product Overview:  Rabbit polyclonal to detect Histone H3.3 (phospho S31)
Antibody Type:  Polyclonal
Immunogen:  Synthetic peptide corresponding to Human Histone H3.3.
Host:  Rabbit
Isotype:  IgG
Purification:  Immunogen affinity purified
Appearance:  Liquid
Formulation:  pH: 7.40; 0.02% Sodium azide, 50% Glycerol, PBS, 0.87% Sodium chloride
Applications:  ICC/IF
Species Reactivity:  Human
Storage:  -20°C.
Warning:  For Research Use Only! Not For Use in Humans.
Accession:  P84243
Alternative Name:  H3 histone family 3A antibody/H3 histone family 3B antibody/H3 histone, family 3B (H3.3B) antibody
Scientific Background:  Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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