| Cat.No.: | PE-0138 |
| Product Name: | Recombinant Human SIRT2, His-tagged |
| Product Overview: | Recombinant human SIRT2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 41.7kDa (372aa). |
| Description: | SIRT2 (NAD-dependent deacetylase sirtuin-2) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. SIRT2 is a NAD-dependent deacetylase, which deacetylates the "Lys-40" of alpha-tubulin. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | > 90% by SDS - PAGE. |
| Species: | Human |
| Formulation: | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 2mM DTT, 200mM NaCl, 0.5mM EDTA. |
| Tag: | His |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDFLRNLFSQ TLSLGSQKER LLDELTLEGV ARY MQSERCR RVICLVGAGI STSAGIPDFR SPSTGLYDNL EKYHLPYPEA IFEISYFKKH PEPFFALAKE LYPGQFKPTI CHYFMRLLKD KGLLLRCYTQ NIDTLERIAG LEQE DLVEAH GTFYTSHCVSASCRHEYPLS WMKEKIFSEV TPKCEDCQSL VKPDI VF FGE SLPARFFSCM QSDFLKVDLL LVMGTSLQVQ PFASLISKAP LSTPRLLINK EK A GQ SDPFL GMIMGLGGGM DFDSKKAYRD VAWLGECDQG CLALAELLGW KKE LEDL VRR EHASIDAQSG AGVPNPSTSA SPKKSPPPAK DEARTTEREK PQ. |
| Expression System: | E. coli |
| Concentrations: | 0.25mg/ml (determined by Bradford assay). |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT2 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) [ Homo sapiens ] |
| Gene ID NCBI: | 22933 |
| Synonyms: | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); SIR2; SIR2L; SIR2L2; SIRT2; sirtuin 2; sirtuin type 2; sir2-related protein type 2; silent information regulator 2; silencing information regulator 2-like; EC 3.5.1.-; SIR2-like; SIR2-like protein 2; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2 |
| mRNA Refseq: | NM_012237 |
| Protein Refseq: | NP_036369 |
| MIM: | 604480 |
| UniProt ID: | Q8IXJ6 |
| Chromosome Location: | 19q13 |
| Function: | NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
